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Article

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.

Molecular microbiology - 1 Feb 2000

Schreiber V, Steegborn C, Clausen T, Boos W, Richet E

Abstract excerpt

MalT, the transcriptional activator of the Escherichia coli maltose regulon, self-associates, binds promoter DNA and activates initiation of transcription only in the presence of ATP and maltotriose, the inducer. In vivo studies have revealed that MalT action is negatively controlled by the MalY protein. Using a biochemical approach, we analyse here the mechanism whereby MalY represses MalT activity. We show that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10692154
DOI: 10.1046/j.1365-2958.2000.01747.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.PMID 10692154Read ↗

Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.Semantic proximity Read ↗

MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator malt by antagonizing inducer binding.Semantic proximity Read ↗

The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.Semantic proximity Read ↗

Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.Semantic proximity Read ↗

The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon.Semantic proximity Read ↗

Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.Semantic proximity Read ↗

Multiple protein-DNA and protein-protein interactions are involved in transcriptional activation by MalT.Semantic proximity Read ↗

How integration of positive and negative regulatory signals by a STAND signaling protein depends on ATP hydrolysis.Semantic proximity Read ↗

Maltose and maltotriose can be formed endogenously in Escherichia coli from glucose and glucose-1-phosphate independently of enzymes of the maltose system.Semantic proximity Read ↗

Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2.Semantic proximity Read ↗

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system.Semantic proximity Read ↗

The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT, a bacterial STAND transcription factor.Semantic proximity Read ↗

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