Article
Nucleotide dependence of the dimerization of ATP binding cassette nucleotide binding domains.
Biochemical and biophysical research communications - 11 Nov 2016
Fendley Gregory A, Urbatsch Ina L, Sutton Roger B, Zoghbi Maria E, Altenberg Guillermo A
Abstract excerpt
ATP-binding cassette proteins are ubiquitously present throughout all known genomes. Their basic functional unit possesses two transmembrane domains and two nucleotide-binding domains. The nucleotide-binding domains are responsible for ATP binding and hydrolysis, and their 3-dimensional structure is conserved across ATP-binding cassette proteins. Binding of ATP produces nucleotide-binding domain dimerization, a...
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