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Article

Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.

Journal of molecular biology - 18 Mar 2005

Richet Evelyne, Joly Nicolas, Danot Olivier

Abstract excerpt

MalT, the dedicated transcriptional activator of the maltose regulon in Escherichia coli, is subject to multiple controls. Maltotriose, the inducer, promotes MalT self-association, a critical step in promoter binding, whereas three proteins acting as negative allosteric effectors (MalK, the ABC-component of the maltodextrin transporter, MalY, and Aes) antagonize maltotriose binding. All of these regulatory...

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Identifiers

PMID: 15733913
DOI: 10.1016/j.jmb.2005.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.PMID 15733913Read ↗

MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator malt by antagonizing inducer binding.Semantic proximity Read ↗

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.Semantic proximity Read ↗

The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.Semantic proximity Read ↗

Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.Semantic proximity Read ↗

The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon.Semantic proximity Read ↗

The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT, a bacterial STAND transcription factor.Semantic proximity Read ↗

Multiple protein-DNA and protein-protein interactions are involved in transcriptional activation by MalT.Semantic proximity Read ↗

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system.Semantic proximity Read ↗

MalFGK complex assembly and transport and regulatory characteristics of MalK insertion mutants.Semantic proximity Read ↗

Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.Semantic proximity Read ↗

How integration of positive and negative regulatory signals by a STAND signaling protein depends on ATP hydrolysis.Semantic proximity Read ↗

The MalT-dependent and malZ-encoded maltodextrin glucosidase of Escherichia coli can be converted into a dextrinyltransferase by a single mutation.Semantic proximity Read ↗

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