Article
gp41 sequence variability in HIV type 1 non-B subtypes infected patients undergoing enfuvirtide pressure.
AIDS research and human retroviruses - 1 Oct 2007
D'Arrigo Roberta, Ciccozzi Massimo, Gori Caterina, Montieri Stefania, Aquaro Stefano, Bellagamba Rita, Boumis Evangelo, Di Perri Giovanni, Pizzi Daniele, Antinori Andrea, Rezza Giovanni, Perno Carlo Federico
Abstract excerpt
Enfuvirtide is the first of a new class of antiretroviral drugs that inhibits HIV entry. It is a 36 amino acid synthetic peptide that mimics the HR2 region of the HIV-1 gp41, preventing the fusion of viral and cellular membranes. Up to now, enfuvirtide was designed based on the HIV-1 B-subtype gp41, and resistance mutations to the fusion inhibitor have been investigated primarily in individuals infected with this...
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