Article
Short communication: high polymorphism rates in the HR1 and HR2 gp41 and presence of primary resistance-related mutations in HIV type 1 circulating in Brazil: possible impact on enfuvirtide efficacy.
AIDS research and human retroviruses - 1 Mar 2010
Teixeira Carla, de Sá-Filho Dercy, Alkmim Wagner, Janini Luiz Mario, Diaz Ricardo Sobhie, Komninakis Shirley
Abstract excerpt
We analyzed the gp41 sequences of 80 HIV-infected enfuvirtide-naive individuals who were eligible to receive this antiretroviral according to Brazilian guidelines. We analyzed the genetic diversity of pol and the heptad repeat 1 and 2 (HR1 and HR2) regions of gp41, and compared the genetic profile of HR1 and HR2 found in PBMCs with the profile found in plasma. The similarity between sequences obtained from DNA...
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