Article
Short communication: high polymorphism rates in the HR1 and HR2 gp41 and presence of primary resistance-related mutations in HIV type 1 circulating in Brazil: possible impact on enfuvirtide efficacy.
AIDS research and human retroviruses - 1 Mar 2010
Teixeira Carla, de Sá-Filho Dercy, Alkmim Wagner, Janini Luiz Mario, Diaz Ricardo Sobhie, Komninakis Shirley
Abstract excerpt
We analyzed the gp41 sequences of 80 HIV-infected enfuvirtide-naive individuals who were eligible to receive this antiretroviral according to Brazilian guidelines. We analyzed the genetic diversity of pol and the heptad repeat 1 and 2 (HR1 and HR2) regions of gp41, and compared the genetic profil...
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