Article
Enfuvirtide (T-20) resistance-related mutations in HIV type 1 subtypes B, C, and F isolates from Brazilian patients failing HAART.
AIDS research and human retroviruses - 1 Feb 2009
Oliveira A C A, Martins A N, Pires A F N P C, Arruda M B, Tanuri A, Pereira H S, Brindeiro R M
Abstract excerpt
The synthetic peptide T-20 (enfuvirtide, EFV) represents the first compound approved by the FDA known as entry inhibitors (EIs). The resistance mutations associated with this new class of antiretroviral drug are located in the first heptad repeat (HR1) region of gp41. Amino acid changes in codons...
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