Article
Assay of HIV gp41 amino acid sequence to identify baseline variation and mutation development in patients with virologic failure on enfuvirtide.
Antiviral research - 1 Jul 2007
Loutfy M R, Raboud J M, Montaner J S G, Antoniou T, Wynhoven B, Smaill F, Rouleau D, Gill J, Schlech W, Brumme Z L, Mo T, Gough K, Rachlis A, Harrigan P R, Walmsley S L
Abstract excerpt
In this study, we retrospectively assessed a gp41 genotypic assay in 404 enfuvirtide-naïve individuals (340 clade B, 64 non-B clade) to determine the prevalence of baseline polymorphisms and in 41 patients virologically failing enfuvirtide to determine correlates of resistance to this agent. Conserved and polymorphic regions of gp41 were identified in clade B isolates, with 127 of 328 codons (38.7%) being highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.