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Article

Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways.

Journal of cellular physiology - 1 May 2008

Raucci Angela, Bellosta Paola, Grassi Roberta, Basilico Claudio, Mansukhani Alka

Abstract excerpt

Skeletal development requires the correct balance of osteoblast proliferation, survival, and differentiation which is modulated by a network of signaling pathways and transcription factors. We have examined the role of the AKT (PKB), and ERK1/2 signaling pathways in the osteoblast response to FGFs, which inhibit differentiation, and to IGF-1 and Wnt signaling, which promote it. Using osteoblastic cell lines as...

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Identifiers

PMID: 17960591
DOI: 10.1002/jcp.21323

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FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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