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Article

Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.

The American journal of pathology - 1 May 1999

Fragale A, Tartaglia M, Bernardini S, Di Stasi A M, Di Rocco C, Velardi F, Teti A, Battaglia P A, Migliaccio S

Abstract excerpt

Craniosynostoses are a heterogeneous group of disorders characterized by premature fusion of cranial sutures. Mutations in fibroblast growth factor receptors (FGFRs) have been associated with a number of such conditions. Nevertheless, the cellular mechanism(s) involved remain unknown. We analyzed cell proliferation and differentiation in osteoblasts obtained from patients with three genetically and clinically...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10329600
DOI: 10.1016/S0002-9440(10)65401-6
PMCID: PMC1866602

Genes

FGFR2
FGF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.PMID 10329600Read ↗

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