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Article

Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.

The American journal of pathology - 1 May 1999

Fragale A, Tartaglia M, Bernardini S, Di Stasi A M, Di Rocco C, Velardi F, Teti A, Battaglia P A, Migliaccio S

Abstract excerpt

Craniosynostoses are a heterogeneous group of disorders characterized by premature fusion of cranial sutures. Mutations in fibroblast growth factor receptors (FGFRs) have been associated with a number of such conditions. Nevertheless, the cellular mechanism(s) involved remain unknown. We analyzed cell proliferation and differentiation in osteoblasts obtained from patients with three genetically and clinically...

Topics

Acrocephalosyndactylia
Alkaline Phosphatase
Cell Differentiation
Cell Division
Cells, Cultured
Craniosynostoses
Humans
Infant
Isoenzymes
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoblasts

Phenotype

Protein Kinase C

Receptors, Fibroblast Growth Factor

Staining and Labeling

Source

Open in PubMed Open full text

Identifiers

PMID: 10329600
DOI: 10.1016/S0002-9440(10)65401-6
PMCID: PMC1866602

Genes

FGFR2
FGF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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