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Article

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.

The Journal of cell biology - 5 Jul 2004

Fujita Takashi, Azuma Yasutaka, Fukuyama Ryo, Hattori Yuji, Yoshida Carolina, Koida Masao, Ogita Kiyokazu, Komori Toshihisa

Abstract excerpt

Runx2 and phosphatidylinositol 3-kinase (PI3K)-Akt signaling play important roles in osteoblast and chondrocyte differentiation. We investigated the relationship between Runx2 and PI3K-Akt signaling. Forced expression of Runx2 enhanced osteoblastic differentiation of C3H10T1/2 and MC3T3-E1 cells and enhanced chondrogenic differentiation of ATDC5 cells, whereas these effects were blocked by treatment with IGF-I...

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Identifiers

PMID: 15226309
DOI: 10.1083/jcb.200401138
PMCID: PMC2172136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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