Article
Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2011
Cheng Ying-Hua, Chitteti Brahmananda R, Streicher Drew A, Morgan Joseph A, Rodriguez-Rodriguez Sonia, Carlesso Nadia, Srour Edward F, Kacena Melissa A
Abstract excerpt
Osteoblasts (OBs) exert a prominent regulatory effect on hematopoietic stem cells (HSCs). We evaluated the difference in hematopoietic expansion and function in response to co-culture with OBs at various stages of development. Murine calvarial OBs were seeded directly (fresh) or cultured for 1, 2, or 3 weeks prior to seeding with 1000 Lin-Sca1 + cKit+ (LSK) cells for 1 week. Significant increases in the following...
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