Article
Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.
Epigenetics - 1 Jan 2015
Jiménez-Chillarón Josep C, Nijland Mark J, Ascensão António A, Sardão Vilma A, Magalhães José, Hitchler Michael J, Domann Frederick E, Oliveira Paulo J
Abstract excerpt
Epigenetics, or regulation of gene expression independent of DNA sequence, is the missing link between genotype and phenotype. Epigenetic memory, mediated by histone and DNA modifications, is controlled by a set of specialized enzymes, metabolite availability, and signaling pathways. A mostly unstudied subject is how sub-toxic exposure to several xenobiotics during specific developmental stages can alter the...
Topics
- Chromatin Assembly and Disassembly
- Developmental Disabilities
- Diet
- Environmental Exposure
- Epigenesis, Genetic
- Genotype
- Humans
- Phenotype
- Xenobiotics