Article
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples.
Leukemia - 1 Feb 2008
Shih L-Y, Liang D-C, Huang C-F, Chang Y-T, Lai C-L, Lin T-H, Yang C-P, Hung I-J, Liu H-C, Jaing T-H, Wang L-Y, Yeh T-C
Abstract excerpt
c-KIT mutations have been described in core-binding factor (CBF) acute myeloid leukemia (AML) at diagnosis. The role of c-KIT mutations in the relapse of CBF-AML is not clear. The role of CSF1R mutation in the pathogenesis of AML remains to be determined. We analyzed receptor tyrosine kinases (RTKs) and Ras mutations on 154 children with AML. Also, we examined the paired diagnosis and relapse samples in CBF-AML....
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