Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-occurrence of KIT and NRAS mutations defines an adverse prognostic core-binding factor acute myeloid leukemia.

Leukemia & lymphoma - 1 Oct 2021

Jin Huimin, Zhu Yu, Hong Ming, Wu Yujie, Qiu Hairong, Wang Rong, Jin Hui, Sun Qian, Fu Jianxin, Li Jianyong, Qian Sixuan, Qiao Chun

Abstract excerpt

Molecular abnormalities are frequent in core-binding factor (CBF) AMLs, but their prognostic relevance is controversial. Sixty-two patients were retrospectively analyzed and 47 harbored at least one gene mutation with a next-generation-sequencing assay. The most common molecular mutation was KIT mutation (30.6%), followed by NRAS (24.2%) and ASXL1 (14.5%) mutations, which was associated with a higher number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Core Binding Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Leukemia, Myeloid, Acute

Share to Membrane Proteins

Share to Mutation

Share to Prognosis

Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 34024223
DOI: 10.1080/10428194.2021.1919660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-occurrence of KIT and NRAS mutations defines an adverse prognostic core-binding factor acute myeloid leukemia.PMID 34024223Read ↗

KIT Mutant/Core binding factor-negative acute myeloid leukemia might be a complex subgroup with dismal prognosis: a single-center retrospective analysis.Semantic proximity Read ↗

Genetic abnormalities predict outcomes in patients with core binding factor acute myeloid leukemiaSemantic proximity Read ↗

[The impact of KIT and other concomitant gene mutations on the prognoses of patients with core-binding factor acute myeloid leukemia].Semantic proximity Read ↗

[Prognostic value of KIT and other clonal genetic mutations in core-binding factor acute myeloid leukemia].Semantic proximity Read ↗

KIT mutations correlate with adverse survival in children with core-binding factor acute myeloid leukemia.Semantic proximity Read ↗

Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities.Semantic proximity Read ↗

Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia.Semantic proximity Read ↗

CNL and aCML should be considered as a single entity based on molecular profiles and outcomes.Semantic proximity Read ↗

KIT mutations confer a distinct gene expression signature in core binding factor leukaemia.Semantic proximity Read ↗

Core‐binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapySemantic proximity Read ↗

Mutational landscape of AML with normal cytogenetics: biological and clinical implications.Semantic proximity Read ↗

Prospective Evaluation of KIT Mutations and Long-Term Outcomes in Pediatric Core Binding Factor Acute Myeloid Leukemia: A Single Institutional Study in China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.