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Article

KIT and FLT3-ITD mutations do not predict outcomes in pediatric core-binding factor acute myeloid leukemia: findings from the C-HUANAN-AML-15 multicenter cohort study.

Annals of hematology - 10 Jun 2026

Zheng Yongzhi, Yu Lihua, Le Shaohua, Li Nainong, Feng Xiaoqin, Li Chunfu, Zheng Mincui, Mai Huirong, Jiang Hua, He Xiangling, Wen Hong, Xu Honggui, Chen Chun, Yang Lihua

Abstract excerpt

Although core-binding factor acute myeloid leukemia (CBF-AML) is generally considered a favorable-risk subtype in children, disease relapse remains a significant concern. The prognostic relevance of co-occurring mutations, particularly KIT and FLT3-ITD, remains debatable, and treatment intensity may modulate their impact. This multicenter analysis included 289 children (< 14 years) with newly diagnosed CBF-AML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42268406
DOI: 10.1007/s00277-026-07112-y
PMCID: PMC13476346

Genes

KIT
FLT3
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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