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Article

KIT mutations correlate with adverse survival in children with core-binding factor acute myeloid leukemia.

Leukemia & lymphoma - 1 Apr 2018

Chen Xi, Dou Hu, Wang Xingjuan, Huang Yi, Lu Ling, Bin Junqing, Su Yongchun, Zou Lin, Yu Jie, Bao Liming

Abstract excerpt

The prevalence and clinical relevance of KIT mutations in childhood core-binding factor (CBF) acute myeloid leukemia (AML) have not been well characterized. In this study, a total of 212 children with de novo AML were enrolled from a Chinese population and 50 (23.5%) of the patients were deemed CBF-AML. KIT mutations were identified in 30% of the CBF-AML cohort. The KIT mutations were clustered in exon 17 and...

Topics

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Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Core Binding Factors
Follow-Up Studies
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progression-Free Survival

Proto-Oncogene Proteins c-kit

Survival Analysis

Source

Identifiers

PMID: 28792268
DOI: 10.1080/10428194.2017.1361025

Genes

KIT
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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KIT mutations correlate with adverse survival in children with core-binding factor acute myeloid leukemia.PMID 28792268Read ↗

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