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Article

Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA

24 Oct 2007

Abstract excerpt

RNA unfolding and folding reactions in physiological conditions can be facilitated by mechanical force one molecule at a time. By using force-measuring optical tweezers, we studied the mechanical unfolding and folding of a hairpin-type pseudoknot in human telomerase RNA in a near-physiological solution, and at room temperature. Discrete two-state folding transitions of the pseudoknot are seen at approximately 10...

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PMID: 17959928
DOI: 10.1261/rna.676707

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