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Article

Mechanically stable knot formed by strand threading in Zika virus RNA confers RNase resistance

2020-07-02

Abstract excerpt

Exoribonuclease-resistant RNAs (xrRNAs) from viruses prevent digestion by host exoribonucleases, creating sub-genomic viral RNAs that can enhance infection and pathogenicity. Novel knotted structures in xrRNAs are proposed to act as mechanical road-blocks to RNases. Studying an xrRNA from Zika virus with optical tweezers, we found that it was the most mechanically stable RNA structure yet observed. The knot folded...

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Identifiers and source

Literature Corpus work
ea17087a-1181-5be3-a29a-448ce233f031
DOI
10.1101/2020.07.01.183129
Open publication

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Mechanically stable knot formed by strand threading in Zika virus RNA confers RNase resistanceDOI 10.1101/2020.07.01.183129
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