Article
Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2010
Eckey Karina, Strutz-Seebohm Nathalie, Katz Guy, Fuhrmann Gloria, Henrion Ulrike, Pott Lutz, Linke Wolfgang A, Arad Michael, Lang Florian, Seebohm Guiscard
Abstract excerpt
RATIONALE: The plateau phase of the ventricular action potential is the result of balanced Ca(2+) influx and K(+) efflux. The action potential is terminated by repolarizing K(+) currents. Under β-adrenergic stimulation, both the Ca(2+)-influx and the delayed rectifier K(+) currents I(K) are stimulated to adjust the cardiac action potential duration to the enhanced heart rate and to ascertain adequate increase in...
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