Article
Differences in the abilities of human tau isoforms to promote microtubule assembly.
Journal of neuroscience research - 1 Sept 1991
Scott C W, Blowers D P, Barth P T, Lo M M, Salama A I, Caputo C B
Abstract excerpt
Three isoforms of human tau protein were compared for their abilities to induce microtubule assembly. The three isoforms, tau 3 (tau containing three microtubule-binding domains), tau 4 (tau containing four microtubule-binding domains) and tau 4L (tau containing four microtubule binding domains plus a 58-amino-acid insert near the N-terminus) were expressed in E. coli and purified using ammonium sulfate...
Topics
- Chromatography, Gel
- Chromatography, Ion Exchange
- Cloning, Molecular
- DNA
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Genetic Variation
- Humans
- Kinetics
- Microtubules
- Molecular Weight