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Article

Tau isoform composition influences rate and extent of filament formation.

The Journal of biological chemistry - 8 Jun 2012

Zhong Qi, Congdon Erin E, Nagaraja Haikady N, Kuret Jeff

Abstract excerpt

The risk of developing tauopathic neurodegenerative disease depends in part on the levels and composition of six naturally occurring Tau isoforms in human brain. These proteins, which form filamentous aggregates in disease, vary only by the presence or absence of three inserts encoded by alternatively spliced exons 2, 3, and 10 of the Tau gene (MAPT). To determine the contribution of alternatively spliced...

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Source

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Identifiers

PMID: 22539343
DOI: 10.1074/jbc.M112.364067
PMCID: PMC3370253

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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