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Article

Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice.

Journal of occupational health - 1 Sept 2007

Kim Yong-Dae, Eom Sang-Yong, Ogawa Masanori, Oyama Tsunehiro, Isse Toyohi, Kang Jong-Won, Zhang Yan Wei, Kawamoto Toshihiro, Kim Heon

Abstract excerpt

Excessive alcohol consumption is associated with increased risks of many diseases including cancer. We evaluated oxidative DNA damage in Aldh2 +/+ and Aldh2 -/- mice after they had been subjected to acute ethanol exposure. Olive tail moment, which was measured using a comet assay, was not increased by ethanol treatment in both Aldh2 +/+ and Aldh2 -/- mice. However, after controlling for the effect of ethanol...

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Share to 8-Hydroxy-2'-Deoxyguanosine
Share to Aldehyde Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Chemical and Drug Induced Liver Injury

Share to Comet Assay

Share to Cytochrome P-450 CYP2E1

Share to Deoxyguanosine

Share to Microsomes, Liver

Source

Identifiers

PMID: 17951967
DOI: 10.1539/joh.49.363

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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