Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of drug-induced birth defects: what is known so far?

Pharmacogenomics - 1 Apr 2011

Wilffert Bob, Altena Judith, Tijink Laurien, van Gelder Marleen M H J, de Jong-van den Berg Lolkje T W

Abstract excerpt

A literature review was performed to collect information on the role of pharmacogenetics in six proposed teratogenic mechanisms associated with drug use during pregnancy: folate antagonism, oxidative stress, angiotensin-converting enzyme inhibition and angiotensin II receptor antagonism, cyclooxygenase-1 and -2 inhibition, 5-hydroxytryptamine-reuptake inhibition and drug transporters in the placenta. Data on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Drug-Induced
Share to Angiotensin-Converting Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Angiotensin Receptor Antagonists

Share to Congenital Abnormalities

Share to Cyclooxygenase 2 Inhibitors

Share to Folic Acid

Share to Folic Acid Antagonists

Share to Teratogens

Source

Identifiers

PMID: 21521026
DOI: 10.2217/pgs.10.201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of drug-induced birth defects: what is known so far?PMID 21521026Read ↗

Genetic susceptibility to teratogens: state of the art.Semantic proximity Read ↗

Pharmacogenetics of Drug-Induced Birth Defects: The Role of Polymorphisms of Placental Transporter ProteinsSemantic proximity Read ↗

Antiepileptic medication during pregnancy: does fetal genotype affect outcome?Semantic proximity Read ↗

Pharmacogenetic screening for susceptibility to fetal malformations in women.Semantic proximity Read ↗

Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring.Semantic proximity Read ↗

Update on new developments in the study of human teratogensSemantic proximity Read ↗

Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studiesSemantic proximity Read ↗

Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.Semantic proximity Read ↗

Importance of gene-environment interactions in the etiology of selected birth defects.Semantic proximity Read ↗

Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.Semantic proximity Read ↗

Medical genetics: 1. Clinical teratology in the age of genomics.Semantic proximity Read ↗

A scientific review: mechanisms of valproate-mediated teratogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.