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Article

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2007

Shen Lanlan, Catalano Paul J, Benson Al B, O'Dwyer Peter, Hamilton Stanley R, Issa Jean-Pierre J

Abstract excerpt

PURPOSE: There are no good genomic markers of survival in patients with advanced colorectal cancer. The CpG island methylator phenotype (CIMP) marks a distinctive pathway in colorectal cancer. We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial. EXPERIMENTAL DESIGN: We studied...

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Identifiers

PMID: 17947473
DOI: 10.1158/1078-0432.CCR-07-1011
PMCID: PMC3575642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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