Article
Participation of the protein Go in multiple aspects of behavior in C. elegans.
Science (New York, N.Y.) - 17 Mar 1995
Mendel J E, Korswagen H C, Liu K S, Hajdu-Cronin Y M, Simon M I, Plasterk R H, Sternberg P W
Abstract excerpt
The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphate-binding protein (G protein) Go from Caenorhabditis elegans is expressed in most neurons, and in the muscles involved in egg laying and male mating. Reduction-of-function mutations in goa-1 caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated...
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