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Antiretroviral Activity and Vif Sensitivity of Rhesus Macaque APOBEC3 Proteins

18 Oct 2007

Abstract excerpt

The inability of human immunodeficiency virus type 1(HIV-1) to replicate in rhesus macaque cells is in part due to the failure of HIV-1 Vif to counteract the restriction factor APOBEC3G. However, in this study we demonstrate that several rhesus macaque APOBEC3 (rhAPOBEC3) proteins are capable of inhibiting HIV-1 infectivity. There was considerable variation in the ability of a panel of Vif proteins to induce...

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PMID: 17942564
DOI: 10.1128/jvi.01760-07

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Antiretroviral Activity and Vif Sensitivity of Rhesus Macaque APOBEC3 ProteinsPMID 17942564Read ↗

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