Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development.

Abstract excerpt

Many studies have supported roles for both genetic and environmental factors in the etiology of schizophrenia. A major hypothesis at present is that schizophrenia is a polygenic disorder where alterations in a set of genes lead to impaired neurodevelopment, which in turn results in altered neurotransmission. Several neurotransmitters, including glutamate, dopamine, serotonin and gamma-amino butyric acid (GABA),...

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