Article
Microsatellite instability in canine mammary gland tumors.
Journal of veterinary internal medicine - 1 Jan 2000
McNiel Elizabeth A, Griffin Kelly L, Mellett Amelia M, Madrill Nicole J, Mickelson James R
Abstract excerpt
BACKGROUND: Genomic instability is a hallmark of cancer and may be required for the accumulation of cancer-causing mutations within cells. One form of genomic instability occurs in tandem nucleotide repeats and is known as microsatellite instability (MSI). HYPOTHESIS: We hypothesized that MSI can be observed in canine mammary gland tumors (MGT) and represents a potential carcinogenic mechanism in dogs. ANIMALS:...
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