Article
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.
PloS one - 1 Jan 2015
Borge Kaja S, Nord Silje, Van Loo Peter, Lingjærde Ole C, Gunnes Gjermund, Alnæs Grethe I G, Solvang Hiroko K, Lüders Torben, Kristensen Vessela N, Børresen-Dale Anne-Lise, Lingaas Frode
Abstract excerpt
BACKGROUND: Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs. RESULTS: We found a high occurrence of copy number aberrations in canine mammary tumours, losses being more...
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