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Article

Targeted deletion of the gp72 gene decreases the infectivity of Trypanosoma cruzi for mice and insect vectors.

The Journal of parasitology - 1 Jun 2002

Basombrío Miguel A, Gómez Laura, Padilla Angel M, Ciaccio Mirella, Nozaki Tomoyoshi, Cross George A M

Abstract excerpt

The infective behavior of a mutant Trypanosoma cruzi clone, carrying a targeted deletion of the gp72 gene, was studied in the insect vector Triatoma infestans and in mice. After feeding T. infestans with complement-resistant forms (CRF) of Ynull and wild-type clones, it was observed that the number of parasites released in the bug's feces was reduced to less than 1% in the mutant clone. Both gp72-null and...

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PMID: 12099416
DOI: 10.1645/0022-3395(2002)088[0489:TDOTGG]2.0.CO;2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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