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Article

Sensitivity to activated protein C during the menstrual cycle in women with and without factor VLeiden.

Thrombosis research - 1 Jan 2008

van Vliet Huib A A M, Rodrigues Sharon P, Snieders Marieke N E, van der Meer Felix J M, Frolich Marijke, Rosendaal Frits R, Rosing Jan, Helmerhorst Frans M

Abstract excerpt

INTRODUCTION: Activated protein C (APC) resistance is associated with an increased risk of venous thrombosis. High levels of estradiol and progesterone, e.g. during ovarian stimulation and pregnancy, as well as exogenously administered estrogens and progestagens during oral contraceptive use, induce an acquired form of APC resistance. Several coagulation factors display a cyclic pattern during the menstrual cycle...

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Identifiers

PMID: 17936879
DOI: 10.1016/j.thromres.2007.08.010

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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