Article
Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.
Blood - 1 Feb 2004
Kemmeren Jeanet M, Algra Ale, Meijers Joost C M, Tans Guido, Bouma Bonno N, Curvers Joyce, Rosing Jan, Grobbee Diederick E
Abstract excerpt
A plausible mechanism to explain thrombotic risk differences associated with the use of second- and third-generation oral contraceptives (OCs), particularly in carriers of factor V(Leiden), is still lacking. In a double-blind trial, 51 women without and 35 women with factor V(Leiden) were randomized to either a second- (30 microg ethinylestradiol/150 microg levonorgestrel) or third- (30 microg...
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