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Article

Alteration of the quaternary structure of human UDP-glucose dehydrogenase by a double mutation.

Journal of biochemistry and molecular biology - 30 Sept 2007

Huh Jae-Wan, Yang Seung-Ju, Hwang Eun Young, Choi Myung-Min, Lee Hyun-Ju, Kim Eun-A, Choi Soo Young, Choi Jene, Hong Hea-Nam, Cho Sung-Woo

Abstract excerpt

There are conflicting views for the polymerization process of human UDP-glucose dehydrogenase (UGDH) and no clear evidence has been reported yet. Based on crystal coordinates for Streptococcus pyogenes UGDH, we made double mutant A222Q/S233G. The double mutagenesis had no effects on expression, stability, and secondary structure. Interestingly, A222Q/S233G was a dimeric form and showed an UGDH activity, although...

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Source

Identifiers

PMID: 17927902
DOI: 10.5483/bmbrep.2007.40.5.690

Genes

UGDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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