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Article

Biochemical Analysis of Two Single Mutants that Give Rise to a Polymorphic G6PD A-Double Mutant.

International journal of molecular sciences - 26 Oct 2017

Ramírez-Nava Edson Jiovany, Ortega-Cuellar Daniel, Serrano-Posada Hugo, González-Valdez Abigail, Vanoye-Carlo America, Hernández-Ochoa Beatriz, Sierra-Palacios Edgar, Hernández-Pineda Jessica, Rodríguez-Bustamante Eduardo, Arreguin-Espinosa Roberto, Oria-Hernández Jesús, Reyes-Vivas Horacio, Marcial-Quino Jaime, Gómez-Manzo Saúl

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme that plays a crucial role in the regulation of cellular energy and redox balance. Mutations in the gene encoding G6PD cause the most common enzymopathy that drives hereditary nonspherocytic hemolytic anemia. To gain insights into the effects of mutations in G6PD enzyme efficiency, we have investigated the biochemical, kinetic, and structural...

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Identifiers

PMID: 29072585
DOI: 10.3390/ijms18112244
PMCID: PMC5713214

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Source receipt: pubmed, retrieved 7 Sept 2026.

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