Effects of Single and Double Mutants in Human Glucose-6-Phosphate Dehydrogenase Variants Present in the Mexican Population: Biochemical and Structural Analysis.

doi:10.3390/ijms21082732

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Article

Effects of Single and Double Mutants in Human Glucose-6-Phosphate Dehydrogenase Variants Present in the Mexican Population: Biochemical and Structural Analysis.

International journal of molecular sciences - 15 Apr 2020

Martínez-Rosas Víctor, Juárez-Cruz Merit Valeria, Ramírez-Nava Edson Jiovany, Hernández-Ochoa Beatriz, Morales-Luna Laura, González-Valdez Abigail, Serrano-Posada Hugo, Cárdenas-Rodríguez Noemí, Ortiz-Ramírez Paulina, Centeno-Leija Sara, Arreguin-Espinosa Roberto, Cuevas-Cruz Miguel, Ortega-Cuellar Daniel, Pérez de la Cruz Verónica, Rocha-Ramírez Luz María, Sierra-Palacios Edgar, Castillo-Rodríguez Rosa Angélica, Baeza-Ramírez Isabel, Marcial-Quino Jaime, Gómez-Manzo Saúl

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most frequent human enzymopathy, affecting over 400 million people globally. Worldwide, 217 mutations have been reported at the genetic level, and only 19 have been found in Mexico. The objective of this work was to contribute to the knowledge of the function and structure of three single natural variants (G6PD A+, G6PD San Luis Potosi, and G6PD...

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PMID: 32326520
DOI: 10.3390/ijms21082732
PMCID: PMC7215812

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