Article
Glucose-6-Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World.
International journal of molecular sciences - 9 Dec 2016
Gómez-Manzo Saúl, Marcial-Quino Jaime, Vanoye-Carlo America, Serrano-Posada Hugo, Ortega-Cuellar Daniel, González-Valdez Abigail, Castillo-Rodríguez Rosa Angélica, Hernández-Ochoa Beatriz, Sierra-Palacios Edgar, Rodríguez-Bustamante Eduardo, Arreguin-Espinosa Roberto
Abstract excerpt
Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is especially important in red blood cells (RBC). Given its central role in the regulation of redox state, it is understandable that mutations in the gene encoding G6PD can cause...
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