Differential regulation of the transcriptional repressor <i>NRG1</i> accounts for altered host‐cell interactions in <i>Candida albicans</i> and <i>Candida dubliniensis</i>

Abstract excerpt

Candida dubliniensis is genetically closely related to Candida albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. dubliniensis transcriptional repressor-encoding gene CdNRG1 in regulating this phenotype. Deletion of both copies of CdNRG1 increased the formation of true hyphae by C. dubliniensis in...

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