An exploration of the genetic robustness landscape of surface protein families in the human protozoan parasite Trypanosoma cruzi.

Abstract excerpt

The ability of genes to be robust to mutations at the codon level has been suggested as a key factor for understanding adaptation features. It has been proposed that genes relevant to host-parasite interactions will tend to exhibit high volatility or "antirobust" patterns, which may be related to the capacity of the parasite to evade the host immune system. We compared two superfamilies of surface proteins,...

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