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Article

Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei

28 May 2008

Abstract excerpt

BACKGROUND: Whole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei, as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous (amino acid retaining) nucleotide substitution rates. METHODOLOGY/PRINCIPAL FINDINGS: We have identified duplicated...

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PMID: 18509460
DOI: 10.1371/journal.pone.0002295

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