Article
Homology, paralogy and function of DGF-1, a highly dispersed Trypanosoma cruzi specific gene family and its implications for information entropy of its encoded proteins.
Molecular and biochemical parasitology - 1 May 2009
Kawashita Silvia Y, da Silva Claudio V, Mortara Renato A, Burleigh Barbara A, Briones Marcelo R S
Abstract excerpt
Surface adhesion proteins are essential for Trypanosoma cruzi invasion of mammalian cells. Here we show that Dispersed Gene Family-1 (DGF-1) members, previously identified as nuclear repeated sequences present in several chromosomes and comprising the third largest T. cruzi specific gene family, have conserved adhesin motifs including four segments with significant similarity to human beta 7 integrin. Flow...
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