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Article

Detecting excess radical replacements in phylogenetic trees.

Gene - 13 Nov 2003

Pupko Tal, Sharan Roded, Hasegawa Masami, Shamir Ron, Graur Dan

Abstract excerpt

There are a few instances in which positive Darwinian selection has been convincingly demonstrated at the molecular level. In this study, we present a novel test for detecting excess of radical amino-acid replacements. Such excess is usually indicative of positive Darwinian selection, but may also be due to relaxed functional constraints or model misspecification. In our test, each amino-acid replacement is...

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PMID: 14597178
DOI: 10.1016/s0378-1119(03)00802-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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