Article
Prevalence of BRCA mutations and founder effect in high-risk Hispanic families.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2005
Weitzel Jeffrey N, Lagos Veronica, Blazer Kathleen R, Nelson Rebecca, Ricker Charité, Herzog Josef, McGuire Colleen, Neuhausen Susan
Abstract excerpt
UNLABELLED: Approximately 12% of the U.S. population is Hispanic, with the majority residing in urban centers such as Los Angeles. The prevalence of BRCA mutations among high-risk Hispanic families is unknown. METHODS: One hundred and ten unrelated probands of Hispanic origin, with a personal or family history of breast and/or ovarian cancer, presented for genetic cancer risk assessment, were enrolled in an...
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