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Article

Modulation of DNA damage/DNA repair capacity by XPC polymorphisms.

DNA repair - 1 Feb 2008

Zhu Yimin, Yang Hushan, Chen Qin, Lin Jie, Grossman H Barton, Dinney Colin P, Wu Xifeng, Gu Jian

Abstract excerpt

XPC, a key protein in the nucleotide excision repair (NER) pathway, recognizes damaged DNA and initiates NER. Genetic variations in the XPC gene might be associated with altered DNA repair capacities (DRC). In this study, we genotyped three XPC polymorphisms, Ala499Val (C-->T), PAT (-/+) and Lys939Gln (A-->C), and measured the DNA damage/DRC by alkaline comet assay challenged by BPDE and gamma-radiation in 476...

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Source

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Identifiers

PMID: 17923445
DOI: 10.1016/j.dnarep.2007.08.006
PMCID: PMC2254649

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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