Article
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.
Journal of hepatology - 1 Dec 2007
Dal Pero Francesca, Di Maira Giovanni, Marin Oriano, Bortoletto Gladis, Pinna Lorenzo A, Alberti Alfredo, Ruzzene Maria, Gerotto Martina
Abstract excerpt
BACKGROUND/AIMS: The hepatitis C virus NS5A protein is phosphorylated by several cellular kinases, including casein kinase 2 (CK2). Little is known about CK2 phosphorylation of NS5A from different HCV genotypes and clinical isolates. METHODS: NS5A from patients with HCV-1a (24 cases), HCV-1b (9) or HCV-3 (16) was analyzed by direct sequencing and CK2 phosphorylation sites were defined using a well-validated...
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