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Article

Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A.

Journal of virology - 15 Sept 2020

Chiang Cho-Han, Lai Yen-Ling, Huang Yu-Ning, Yu Chun-Chiao, Lu Christine C, Yu Guann-Yi, Yu Ming-Jiun

Abstract excerpt

Replication of the genotype 2 hepatitis C virus (HCV) requires hyperphosphorylation of the nonstructural protein NS5A. It has been known that NS5A hyperphosphorylation results from the phosphorylation of a cluster of highly conserved serine residues (S2201, S2208, S2211, and S2214) in a sequential manner. It has also been known that NS5A hyperphosphorylation requires an NS3 protease encoded on one single NS3-5A...

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Identifiers

PMID: 32699091
DOI: 10.1128/JVI.00420-20
PMCID: PMC7495366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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