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Article

Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly.

The Journal of biological chemistry - 17 Oct 2008

Jirasko Vlastimil, Montserret Roland, Appel Nicole, Janvier Anne, Eustachi Leah, Brohm Christiane, Steinmann Eike, Pietschmann Thomas, Penin Francois, Bartenschlager Ralf

Abstract excerpt

The hepatitis C virus (HCV) is a flavivirus replicating in the cytoplasm of infected cells. The HCV genome is a single-stranded RNA encoding a polyprotein that is cleaved by cellular and viral proteases into 10 different products. While the structural proteins core protein, envelope protein 1 (E1) and E2 build up the virus particle, most nonstructural (NS) proteins are required for RNA replication. One of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18644781
DOI: 10.1074/jbc.M803981200
PMCID: PMC2661407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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