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Article

Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S).

PloS one - 1 Jan 2014

Kim Seungtaek, Jin Bora, Choi Sung Hoon, Han Kwang-Hyub, Ahn Sang Hoon

Abstract excerpt

Genotype 2a JFH1 virus has substantially contributed to the progress of HCV biology by allowing entire viral life cycle of HCV in cell culture. Using this genotype 2a virus, casein kinase II (CKII) was previously identified as a crucial host factor in virus assembly by phosphorylating NS5A. Since most of the prior studies employed genotype 2a JFH1 or JFH1-based intragenotypic chimera, we used genotype 1a H77S to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25464014
DOI: 10.1371/journal.pone.0113938
PMCID: PMC4252060

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