The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.

doi:10.1093/hmg/ddm292

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.

Human molecular genetics - 15 Jan 2008

Van Laer Lut, Van Eyken Els, Fransen Erik, Huyghe Jeroen R, Topsakal Vedat, Hendrickx Jan-Jaap, Hannula Samuli, Mäki-Torkko Elina, Jensen Mona, Demeester Kelly, Baur Manuela, Bonaconsa Amanda, Mazzoli Manuela, Espeso Angeles, Verbruggen Katia, Huyghe Joke, Huygen Patrick, Kunst Sylvia, Manninen Minna, Konings Annelies, Diaz-Lacava Amalia N, Steffens Michael, Wienker Thomas F, Pyykkö Ilmari, Cremers Cor W R J, Kremer Hannie, Dhooge Ingeborg, Stephens Dafydd, Orzan Eva, Pfister Markus, Bille Michael, Parving Agnete, Sorri Martti, Van de Heyning Paul H, Van Camp Guy

Abstract excerpt

Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Europe

Share to Introns

Share to Linkage Disequilibrium

Share to Presbycusis

Share to Protein Isoforms

Share to Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 17921507
DOI: 10.1093/hmg/ddm292

Genes

GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.PMID 17921507Read ↗

The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese.Semantic proximity Read ↗

The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis.Semantic proximity Read ↗

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.Semantic proximity Read ↗

The genetic landscape of age-related hearing loss.Semantic proximity Read ↗

Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.Semantic proximity Read ↗

Molecular genetic epidemiology of age-related hearing impairment.Semantic proximity Read ↗

A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.Semantic proximity Read ↗

Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms.Semantic proximity Read ↗

[Association between grainyhead-like 2 gene polymorphisms and noise-induced hearing loss].Semantic proximity Read ↗

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.Semantic proximity Read ↗

New insights into the complex genetic architecture of age-related hearing loss.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.