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Article

Synergistic activity of the ninth and tenth FIII domains of human fibronectin depends upon structural stability.

The Journal of biological chemistry - 3 Jan 2003

Altroff Harri, Choulier Laurence, Mardon Helen J

Abstract excerpt

The ninth and tenth FIII domains (FIII9-10) of human fibronectin act in synergy to promote cell adhesion via the interaction with integrin receptors. Here we describe the functional and structural properties of a set of recombinant FIII9-10 mutants containing various alanine substitutions within the key synergistic site, DRVPHSRN in FIII9, either alone or in combination with another substitution (Leu(1408) to...

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Identifiers

PMID: 12376529
DOI: 10.1074/jbc.M209992200
PMCID: PMC1626583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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