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Article

Novel mutant human fibronectin FIII9-10 domain pair with increased conformational stability and biological activity.

Protein engineering - 1 Dec 2002

van der Walle Christopher F, Altroff Harri, Mardon Helen J

Abstract excerpt

The ninth and tenth type III domains (FIII9-10) in the central cell binding domain of human fibronectin contain integrin receptor binding sites, including RGD in FIII10 and a synergy site, PHSRN, in FIII9. The specific amino acids that contribute to cell binding have been identified by the use of wild-type and mutant fragments of human fibronectin containing the FIII9-10 domain pair. At high concentrations...

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Identifiers

PMID: 12601142
DOI: 10.1093/protein/15.12.1021
PMCID: PMC1630685

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Source receipt: pubmed, retrieved 7 Sept 2026.

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